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KMID : 0363220120500080742
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Korean Journal of Dermatology
2012 Volume.50 No. 8 p.742 ~ p.746
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A Case of Dermatomyositis with Acute Interstitial Pneumonitis Manifested as Antisynthetase Syndrome
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Son Hyun-Ho
Jung Se-Won
Shim Hyun-Soo
Lee Sook-Kyung
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Abstract
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Dermatomyositis is a systemic inflammatory disease affecting the skin, skeletal muscle, and occasionally, other organs, such as the lung. Interstitial lung disease (ILD) is a serious lung complication, which can occur in patients with dermatomyositis. It affects the prognosis of the disease and requires a more aggressive therapeutic approach. Interstitial lung disease (ILD) may be associated with systemic inflammatory disorders and autoantibody production. In particular, anti Jo-1 antibody has long been recognized as an important predictive factor in systemic manifestations of ILD in dermatomyositis. We report here a case of a 42 year old woman with cutaneous lesions typical of dermatomyositis, showing clinical features of antisynthetase syndrome, which showed rapid progression to acute respiratory distress syndrome.
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KEYWORD
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Antisynthetase syndrome, Dermatomyositis, Interstitial lung disease
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